FUB-AMB/ AMB-FUBINACA (also known as MMB-FUBINACA) is an indazole-based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with Ki values of 10.04 nM at CB1 and 0.786 nM at CB2 and EC50 values of 0.5433 nM at CB1 and 0.1278 nM at CB2, and has been sold online as a designer drug. It was originally developed by Pfizer which described the compound in a patent in 2009, but was later abandoned and never tested on humans.
On July 12, 2016 the New York City Emergency Medical Services (EMS) responded to a “mass casualty event” in Brooklyn, New York,where 33 people ranging in age from 25 to 59 years old were adversely affected by the drug. 18 were hospitalized. All of the victims were described by by-standers as “zombielike” and the cause was attributed to use of AMB-FUBINACA as the demethylated metabolite was found in the blood and urine of eight of the hospitalized patients that had been sent for testing by the DEA. Screening for the more usual drugs of abuse was negative in all 8 patients. AMB-FUBINACA itself was found in a sample from the product smoked by another patient. The metabolite was identified after 10 days and the FUB-AMB/ AMB-FUBINACA was only confirmed 17 days after the incident.
Up to 20 deaths in New Zealand have also been attributed to FUB-AMB/ AMB-FUBINACA during 2017, with tested products containing between 32 mg/g and 400 mg/g of the active ingredient, between 2x to 25x stronger than the product involved in the mass casualty event in New York a year earlier.
The state of Louisiana banned FUB-AMB/ AMB-FUBINACA through an emergency rule after it was detected in a synthetic cannabis product called “Train Wreck 2” which had been linked to adverse events and seizures on 3 June 2014.
Sweden’s public health agency suggested classifying as a hazardous substance on November 10, 2014